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REVIEW ARTICLES
NUMBER 4 YEAR 2007
Intrahepatic Cholestasis of Pregnancy: A Review of Epidemiology, Clinical Features, Fetal Risks, Treatment, and Management
1 Department of Dermatovenerology, Victor Babes University of Medicine and Pharmacy, Timisoara, 2 Ana Aslan Geriatric and Gerontologic Institute, Bucharest

Correspondence to:
Maria-Magdalena Paunescu, Department of Dermato-venerology, 5 Marasesti Str., Timisoara, Tel. +40-726-016310
Email: magdalenapaunescu@yahoo.com
REZUMAT
Colestaza intrahepatica de sarcina este o forma reversibila de colestaza care apare la paciente cu predispozitie genetica in ultimele luni de sarcina. Ea se caracterizeaza clinic prin prurit si leziuni tegumentare exclusiv secundare. Semnificatia cunoasterii acestei dermatoze consta in asocierea ei cu riscuri fetale precum nasterea prematura, mortalitatea fetala perinatala si stress-ul fetal. Aceasta asociere face necesara cooperarea interdisciplinara intre medici dermatologi, gastroenterologi, obstetricieni si pediatri. Scopul acestui articol este de a sublinia caracteristicile clinice, de laborator si management-ul colestazei intrahepatice de sarcina, in vederea evitarii riscurilor fetale.

ABSTRACT
Intrahepatic cholestasis of pregnancy is a reversible form of cholestasis, in genetically predisposed individuals, in late pregnancy. It is clinically characterised by the presence of pruritus and exclusively secondary skin lesions. The importance of knowing this dermatosis lies in the fact that is associated with fetal risks like prematurity, stillbirth and fetal distress. This is the reason why an interdisciplinary management between dermatologists, gastroenterologists, obstetricians and paediatricians is necessary. The purpose of this article is to delineate the clinical features, laboratory findings, and the management of intrahepatic cholestasis of pregnancy in order to avoid fetal risks.


"Victor Babes" Publishing House "Victor Babes" University of Medicine and Pharmacy Romanian Academy of Medical Sciences National Council of Scientific Research in Higher Education (B+) Index Copernicus
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