TY  - EJOU
AU  - Ulici, U. Alexandra
AU  - Milan, M. Andreea
AU  - Mioc, M. Marius
AU  - Ghiulai, G. Roxana
AU  - Racoviceanu, R. Roxana
AU  - Șoica, Ș. Codruța
TI  - Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds
T2  - Timisoara Medical Journal

PY  - 2021
VL  - 2020
IS  - 2
SN  - 1583-526X

AB  - Pentacyclic triterpenes represent an important class of intensively studied substances in the past two decades due to their wide spectrum of pharmacological effects. Even though this class is being thoroughly researched for the development of new drugs, to date, no representative has qualified to become a suitable candidate for various therapies. Although a large part of past and ongoing studies focuses on triterpene chemical derivatization or formulation to increase its bioavailability, other researchers are focused on obtaining semisynthetic derivatives not necessarily with increased hydrophilicity but with a superior biological effect compared to their parent compound. The current review aims to report the biological assessment of several ring-modified pentacyclic triterpene derivative series.
KW  - pentacyclic triterpenes
KW  - ring derivatization
KW  - synthetic derivatives
KW  - biological activity
DO  - 10.35995/tmj20200207