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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">Timisoara_Med</journal-id>
      <journal-title-group>
        <journal-title>TIMISOARA MEDICAL JOURNAL</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Timisoara_Med</abbrev-journal-title>
        <abbrev-journal-title abbrev-type="pubmed">TIMISOARA MEDICAL JOURNAL</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">1583-526X</issn>
      <publisher>
        <publisher-name>Victor Babes University of Medicine and Pharmacy Timisoara</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.35995/tmj20240101</article-id>
      <article-id pub-id-type="publisher-id">Timisoara_Med-2024-2</article-id>
      <article-categories>
        <subj-group>
          <subject>Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Perceptions and Knowledge of Orthodontic Treatment by an Adult Group in Romania</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Georgescu</surname>
            <given-names>Raluca-&#x218;tefania</given-names>
          </name>
          <xref rid="af1-ijms-3036920" ref-type="aff">1</xref>
          <xref rid="c1-ijms-3036920" ref-type="corresp">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Oancea</surname>
            <given-names>Roxana</given-names>
          </name>
          <xref rid="af2-ijms-3036920" ref-type="aff">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-9391-7341</contrib-id>
          <name>
            <surname>Sfeatcu</surname>
            <given-names>Ruxandra</given-names>
          </name>
          <xref rid="af3-ijms-3036920" ref-type="aff">3</xref>
        </contrib>
      </contrib-group>
      <aff id="af1-ijms-3036920"><label>1</label>Pediatric Dental Specialist, Private Clinic, 011981 Bucharest, Romania</aff>
      <aff id="af2-ijms-3036920"><label>2</label>Preventive, Community Dentistry and Oral Health Department, &#x201D;Victor Babe&#x219;&#x201D; University of Medicine and Pharmacy, 300041 Timi&#x219;oara, Romania; <email>roancea@umft.ro</email></aff>
      <aff id="af3-ijms-3036920"><label>3</label>Oral Health and Community Dentistry Department, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 010221Bucharest, Romania; <email>ruxandra.sfeatcu@umfcd.ro</email></aff>
      <author-notes>
        <corresp id="c1-ijms-3036920"><label>*</label>Correspondence: <email>contact@ralucageorgescu.doctor</email>; Tel.: +40-727-634-078</corresp>
      </author-notes>
      <pub-date pub-type="epub">
        <day>25</day>
        <month>06</month>
        <year>2024</year>
      </pub-date>
      <volume>2024</volume>
      <issue>1</issue>
      <elocation-id>1</elocation-id>
      <history>
        <date date-type="received">
          <day>11</day>
          <month>04</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>15</day>
          <month>06</month>
          <year>2024</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>&#xA9; 2024 Copyright by the authors.</copyright-statement>
        <copyright-year>2024</copyright-year>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <license-p>Licensed as an open access article using a CC BY 4.0 license.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>This paper aims to study an adult population&#x2019;s perception and knowledge of orthodontic treatment within the context of Romania, aiming to underscore the pivotal role of this kind of treatment in improving oral health and enhancing quality of life. Acknowledging malocclusion as a prevalent oral health issue, it is observed that while an increasing number of people seek orthodontic treatment, significant misperceptions remain, emphasizing the need for patient adherence to and knowledge of the effective planification of orthodontic treatment plans. Utilizing a cross-sectional methodology, the authors developed a questionnaire and disseminated it via social media platforms to examine the attitudes and awareness levels among 132 Romanian adults regarding orthodontic treatment. The findings reveal a strong awareness concerning orthodontic procedures. Most of the subjects (61.4%) were of the opinion that, during orthodontic treatment, patients look good and 80.3% assessed the treatment as being expensive. In total, 73.5% of the participants were aware that during orthodontic treatment patients have food restrictions and that neglect can affect the treatment, while 78% thought that brackets and wires can break if care is not taken. Notably, respondents with prior orthodontic treatment showed a higher level of comprehension of the process, including an acknowledgment of the necessity for augmented oral hygiene practices and the implications of non-compliance. The results show a generally affirmative opinion on orthodontic treatment, with a recognition of its long-term benefits for oral health and aesthetics. Nevertheless, the perceived economic and physical barriers to access, underscore a need for patient education. In summary, understanding patient perceptions and knowledge of orthodontic treatment not only fosters enhanced patient&#x2013;orthodontist relationships but also empowers dental professionals to customize educational strategies that amplify treatment efficacy. The study advocates for sustained efforts to disseminate information related to orthodontic care, promoting its benefits as a key aspect of oral health.</p>
      </abstract>
      <kwd-group>
        <kwd>malocclusion</kwd>
        <kwd>orthodontics</kwd>
        <kwd>knowledge</kwd>
        <kwd>perception</kwd>
      </kwd-group>
	  <counts>
        <page-count count="7"/>
      </counts>
	  <custom-meta-group>
        <custom-meta>
          <meta-name>How to cite</meta-name>
          <meta-value>Georgescu, R.-&#x218;.; Oancea, R.; Sfeatcu, R. Perceptions and Knowledge of Orthodontic Treatment by an Adult Group in Romania. <italic>Timisoara Med.</italic> <bold>2024</bold>, <italic>2024</italic>(1), 1; doi:<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.35995/tmj20240101">10.35995/tmj20240101</ext-link>.</meta-value>
        </custom-meta>
      </custom-meta-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="intro">
      <title>Introduction</title>
      <p>Oral health, an important aspect of general health, is still one of the most frequently encountered health issues at global level, although dental caries and periodontal disease is highly preventable [<xref ref-type="bibr" rid="B1-ijms-3036920">1</xref>]. Another common oral health problem that can influence patients&#x2019; quality of life is malocclusion, affecting people both psychosocially, due to its impact on aesthetics and functionality, including impeding mastication, speech, and swallowing [<xref ref-type="bibr" rid="B2-ijms-3036920">2</xref>]. Malocclusion has been established to be the third most common oral health problem [<xref ref-type="bibr" rid="B3-ijms-3036920">3</xref>], and a recent systematic review and meta-analysis on the prevalence of malocclusion in children and adolescents concluded that the worldwide prevalence was around 56% [<xref ref-type="bibr" rid="B4-ijms-3036920">4</xref>]. Consequently, the need for orthodontic treatment is imperative in terms of overcoming the associated problems and for patients to live a healthy life. </p>
      <p>Patients are more aware of aesthetic concerns, thus the number of patients seeking orthodontic treatment has increased, but misconceptions about orthodontic treatment continue to persist. </p>
      <p>Successful orthodontic treatment depends on a multitude of factors, but mainly on patient compliance. For the orthodontic treatment to proceed as planned, patients need to understand the importance of attending appointments, maintaining good oral hygiene, and limiting damage to appliances [<xref ref-type="bibr" rid="B5-ijms-3036920">5</xref>]. Consequently, it is very important for orthodontists&#x2019; first step being to assess patient perceptions and knowledge of orthodontic treatment, to better address their needs. An orthodontist possessing prior information about the knowledge, attitude, and dental hygiene practices of patients can be a key part of the process of estimating a patient&#x2019;s compliance, but also an important aid in formulating solutions in order to improve compliance for better clinical outcomes [<xref ref-type="bibr" rid="B3-ijms-3036920">3</xref>]. </p>
      <p>On the other hand, factors that influence patients to avoid seeking orthodontic treatment are multifarious. In previously conducted studies, the main reason for a discouraged attitude was the high cost of treatment, followed by apprehension of pain, a time-consuming process, and a lack of awareness about the importance of oral hygiene during orthodontic treatment [<xref ref-type="bibr" rid="B6-ijms-3036920">6</xref>]. Multiple studies have been conducted worldwide in order to address the attitude of patients towards malocclusion and the need of orthodontic treatment, most of them finding that patients possess a good level of knowledge of orthodontic treatment but were found to be deficient in terms of attitudes and practice [<xref ref-type="bibr" rid="B3-ijms-3036920">3</xref>]. There has been a lack of these types of studies in Romania; therefore, the aim of the current study is to evaluate the knowledge and perceptions of the adult general population of Romania towards orthodontic treatment and to compare our findings with those from the rest of the world. </p>
    </sec>
    <sec>
      <title>Materials and Methods</title>
      <p>A cross-sectional study was conducted among the adult population of Romania. A structured questionnaire, comprising 15 questions across knowledge and attitudes, was administered. The questionnaire was formulated and written in Romanian and sent to the study participants through social media. </p>
      <p>The questionnaire is composed of three parts&#x2014;the first part includes questions regarding demographic information, such as age, gender, and level of education. The second part comprises questions that were assessed through 3 responses: one correct, one incorrect, and one reflecting uncertainty. The last part was a question regarding the participants&#x2019; background in terms of orthodontic treatment. The answers were confidential; no other information was requested. The study sample included 132 participants above 18 years old and was conducted during February&#x2013;March 2024. </p>
      <p>The sample consisted of 132 adult participants (18&#x2013;54 years old), 62.1% being females and 37.9% being males. The educational background of most participants (77.3%) was secondary studies (university/master&#x2019;s), 13.6% of the participants had a tertiary studies background (PhD/post-graduate studies), and 9.1% had only graduated from high school. </p>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>In the studied group, the majority of the participants (61.4%, <italic>n</italic> = 132) thought that orthodontic treatment is not an esthetic concern and that patients look good during the treatment. Only 16.7% of subjects thought the opposite.</p>
      <p>Regarding the financial cost, the majority of the participants (80.3%) thought that orthodontic treatment is expensive, with only 9.1% thinking the opposite. </p>
      <p>The majority perception (78.8%) was that orthodontic treatment lasts for a long time, most thought that it is painful (48.5%), and most of the participants (40.2%) also thought that orthodontic treatment has a positive impact on both the social and personal aspects of patients&#x2019; lives. The overall perception of the participants (97.7%) was that, after orthodontic treatment, patients smile more confidently, with only 0.8% thinking the opposite (<xref ref-type="table" rid="ijms-3036920-t001">Table 1</xref>). </p>
	  <table-wrap id="ijms-3036920-t001" position="anchor">
        <object-id pub-id-type="pii">ijms-3036920-t001_Table 1</object-id>
        <label>Table 1</label>
        <caption>
          <p>Perceptions of orthodontic treatment.</p>
        </caption>
        <table>
          <thead>
            <tr>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">Question</th>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">True</th>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">False</th>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">Don&#x2019;t Know</th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left" valign="top">Patients wearing orthodontic appliance are looking good</td>
              <td align="left" valign="top">61.4% (81)</td>
              <td align="left" valign="top">16.7% (22)</td>
              <td align="left" valign="top">22% (29)</td>
            </tr>
            <tr>
              <td align="left" valign="top">Orthodontic treatment is expensive</td>
              <td align="left" valign="top">80.3% (106)</td>
              <td align="left" valign="top">9.1% (12)</td>
              <td align="left" valign="top">10.6% (14)</td>
            </tr>
            <tr>
              <td align="left" valign="top">Orthodontic treatment lasts for a long time</td>
              <td align="left" valign="top">78.8% (104)</td>
              <td align="left" valign="top">8.3% (11)</td>
              <td align="left" valign="top">12.9% (17)</td>
            </tr>
            <tr>
              <td align="left" valign="top">Orthodontic treatment hurts</td>
              <td align="left" valign="top">48.5% (64)</td>
              <td align="left" valign="top">31.8% (42)</td>
              <td align="left" valign="top">19.7% (26)</td>
            </tr>
            <tr>
              <td align="left" valign="top" style="border-bottom:solid thin">At the end of orthodontic treatment, patients smile more confidently</td>
              <td align="left" valign="top" style="border-bottom:solid thin">97.7% (129)</td>
              <td align="left" valign="top" style="border-bottom:solid thin">0.8% (1)</td>
              <td align="left" valign="top" style="border-bottom:solid thin">1.5% (2)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>There are slight differences between participants&#x2019; perceptions depending on whether they had or had not worn an orthodontic appliance in the past. The percentage of people deeming orthodontic treatment to be expensive was higher for the participants who had had an orthodontic treatment in the past than for those who had not. There were no significant differences regarding perceptions of the duration of the treatment (<xref ref-type="table" rid="ijms-3036920-t002">Table 2</xref>).</p>
	  <table-wrap id="ijms-3036920-t002" position="anchor">
        <object-id pub-id-type="pii">ijms-3036920-t002_Table 2</object-id>
        <label>Table 2</label>
        <caption>
          <p>Perceptions of orthodontic treatment, comparison between patients with and without braces.</p>
        </caption>
        <table>
          <thead>
            <tr>
              <th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin">Question</th>
              <th colspan="3" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin">With Braces</th>
              <th colspan="3" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin">Without Braces</th>
            </tr>
            <tr>
              <th align="center" valign="middle" style="border-bottom:solid thin">True</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">False</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">Don&#x2019;t Know</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">True</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">False</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">Don&#x2019;t Know</th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Patients wearing orthodontic appliance are looking good</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">67% (36)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">9% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">24% (13)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">58% (45)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">22% (17)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">21% (16)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Orthodontic treatment is expensive</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">85% (46)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">13% (7)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">2% (1)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">77% (60)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">6% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">17% (13)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Orthodontic treatment lasts for a long time</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">87% (47)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">11% (6)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">2% (1)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">73% (57)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">6% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">21% (16)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Orthodontic treatment hurts</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">52% (28)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">43% (23)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">6% (3)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">46% (36)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">24% (19)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">29% (23)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">At the end of orthodontic treatment, patients smile more confidently</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">100% (54)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">-</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">-</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">96% (75)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">1% (1)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">3% (2)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>All the participants that had orthodontic treatment in the past thought that those who had received orthodontic treatment smile more confidently (<xref ref-type="table" rid="ijms-3036920-t002">Table 2</xref>).</p>
      <p>Most of the participants (65.9%) did not think that patients are more prone to developing cavities during orthodontic treatment, and they were aware that during the treatment patients need to take better care of their oral hygiene: 90.9% considered the use of oral irrigators and interdental brushes a must and 79.5% thought that brushing needs to be carried out more frequently and rigorously (<xref ref-type="table" rid="ijms-3036920-t002">Table 2</xref>).</p>
      <p>Most of the participants in the current study (73.5%) were aware that, during orthodontic treatment, patients have food restrictions and that neglect can affect the treatment, with 78% thinking that brackets and wires can break if care is not taken, and with the majority of the participants (73.5%) thinking that patients need to regularly visit their orthodontist, otherwise the situation can worsen&#x2014;patient compliance being an important part of the success of an orthodontic treatment (<xref ref-type="table" rid="ijms-3036920-t003">Table 3</xref>).</p>
	  <table-wrap id="ijms-3036920-t003" position="anchor">
        <object-id pub-id-type="pii">ijms-3036920-t003_Table 3</object-id>
        <label>Table 3</label>
        <caption>
          <p>Knowledge about orthodontic treatment among respondents.</p>
        </caption>
        <table>
          <thead>
            <tr>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">Question</th>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">True</th>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">False</th>
              <th align="left" valign="top" style="border-top:solid thin;border-bottom:solid thin">Do Not Know</th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left" valign="top">Orthodontic treatment moves teeth</td>
              <td align="left" valign="top">58.3% (77)</td>
              <td align="left" valign="top">18.2% (24)</td>
              <td align="left" valign="top">23.5% (31)</td>
            </tr>
            <tr>
              <td align="left" valign="top">Orthodontic treatment harmonizes teeth and bones</td>
              <td align="left" valign="top">83.3% (110)</td>
              <td align="left" valign="top">3.8% (5)</td>
              <td align="left" valign="top">12.9% (17)</td>
            </tr>
            <tr>
              <td align="left" valign="top">During orthodontic treatment, toothbrushing must be done more often and rigorously</td>
              <td align="left" valign="top">79.5% (105)</td>
              <td align="left" valign="top">5.3% (7)</td>
              <td align="left" valign="top">15.2% (20)</td>
            </tr>
            <tr>
              <td align="left" valign="top">During orthodontic treatment, patients must use additional hygiene tools such as interdental brushes/oral irrigator</td>
              <td align="left" valign="top">90.9% (120)</td>
              <td align="left" valign="top">3% (4)</td>
              <td align="left" valign="top">6.1% (8)</td>
            </tr>
            <tr>
              <td align="left" valign="top">Orthodontic treatment determines more cavities</td>
              <td align="left" valign="top">6.1% (8)</td>
              <td align="left" valign="top">65.9% (87)</td>
              <td align="left" valign="top">28% (37)</td>
            </tr>
            <tr>
              <td align="left" valign="top">During orthodontic treatment, patients have food restrictions</td>
              <td align="left" valign="top">73.5% (97)</td>
              <td align="left" valign="top">9.1% (12)</td>
              <td align="left" valign="top">17.4% (23)</td>
            </tr>
            <tr>
              <td align="left" valign="top">Brackets and wires can break because of patients&#x2019; neglect</td>
              <td align="left" valign="top">78% (103)</td>
              <td align="left" valign="top">5.3% (7)</td>
              <td align="left" valign="top">16.7% (22)</td>
            </tr>
            <tr>
              <td align="left" valign="top" style="border-bottom:solid thin">If patients don&#x2019;t respect doctor&#x2019;s recommendation, the situation can worsen</td>
              <td align="left" valign="top" style="border-bottom:solid thin">73.5% (97)</td>
              <td align="left" valign="top" style="border-bottom:solid thin">4.5% (6)</td>
              <td align="left" valign="top" style="border-bottom:solid thin">22% (29)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>Regarding the level of knowledge, participants who had had orthodontic treatment in the past had a higher level of awareness about the rules of orthodontic treatment and had a better understanding the role it plays. The opposite was observed only for the question regarding the failing to adhere to a dentist&#x2019;s recommendations (<xref ref-type="table" rid="ijms-3036920-t004">Table 4</xref>).</p>
	  <table-wrap id="ijms-3036920-t004" position="anchor">
        <object-id pub-id-type="pii">ijms-3036920-t004_Table 4</object-id>
        <label>Table 4</label>
        <caption>
          <p>Knowledge about orthodontic treatment, comparison between patients with and without braces.</p>
        </caption>
        <table>
          <thead>
            <tr>
              <th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin">Question</th>
              <th colspan="3" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin">With Braces</th>
              <th colspan="3" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin">Without Braces</th>
            </tr>
            <tr>
              <th align="center" valign="middle" style="border-bottom:solid thin">True</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">False</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">Don&#x2019;t Know</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">True</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">False</th>
              <th align="center" valign="middle" style="border-bottom:solid thin">Don&#x2019;t Know</th>
            </tr>
          </thead>
          <tbody>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Orthodontic treatment moves teeth</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">74.1% (40)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">18.5% (10)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">7.4% (4)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">47.4% (37)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">17.9% (14)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">34.6% (27)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Orthodontic treatment harmonizes teeth and bones</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">92.6% (50)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">5.6% (3)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">1.9% (1)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">76.9% (60)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">2.6% (2)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">20.5% (16)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">During orthodontic treatment, toothbrushing must be done more often and rigorously</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">96.3% (52)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">3.7% (2)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">-</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">67.9% (53)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">6.4% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">25.6% (20)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">During orthodontic treatment, patients must use additional hygiene tools such as interdental brushes/oral irrigator</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">96.3% (52)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">3.7% (2)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">-</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">87.2% (68)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">2.6% (2)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">10.3% (8)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Orthodontic treatment determines more cavities</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">5.6% (3)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">75.9% (41)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">18.5% (10)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">6.4% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">59.0% (46)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">34.6% (27)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">During orthodontic treatment, patients have food restrictions</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">77.8% (42)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">16.7% (9)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">5.6% (3)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">70.5% (55)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">3.8% (3)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">25.6% (20)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">Brackets and wires can break because of patients&#x2019; neglect</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">85.2% (46)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">9.3% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">5.6% (3)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">73.1% (57)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">2.6% (2)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">24.4% (19)</td>
            </tr>
            <tr>
              <td align="left" valign="middle" style="border-bottom:solid thin">If patients don&#x2019;t respect doctor&#x2019;s recommendation, the situation can worsen.</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">72.2% (39)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">9.3% (5)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">18.5% (10)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">74.4% (58)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">1.3% (1)</td>
              <td align="center" valign="middle" style="border-bottom:solid thin">24.4% (19)</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>Regarding the effects of orthodontic treatment, most of the participants (83.3%) thought that orthodontic treatments harmonize teeth and bones and 84.1% thought that, after active treatment, patients need to wear a retainer in order to maintain the results (<xref ref-type="table" rid="ijms-3036920-t004">Table 4</xref>).</p>
      <p>There were slight differences between the patients who had previously had orthodontic treatment and those who had not, even though the majority follows the same pattern of answers. Most of the participants who had not had orthodontic treatment in the past lean towards an &#x201C;I don&#x2019;t know&#x201D; answer. For example, regarding the notion that orthodontic treatment harmonizes teeth, most participants were aware of the effect, but there are differences between the group that had had braces before (92.6%) and those who had not had braces before (76.9%). For the same question, only 5.6% of the participants who had had braces before answered &#x201C;I don&#x2019;t know&#x201D;, compared to 20.5% of those ones who had not had orthodontic treatment before (<xref ref-type="table" rid="ijms-3036920-t004">Table 4</xref>). </p>
      <p>The same pattern is evident in the question regarding patient neglect&#x2014;with only 5.6% of the patients who had had treatment answering &#x201C;I don&#x2019;t know&#x201D; and 24.4% of those who had not had treatment selecting the same answer. </p>
      <p>Most of the participants in the study are aware that during orthodontic treatment patients have food restrictions (77.8% for the participants who had had braces before and 70.5% for the patients who had not had braces before), with 25.6% of those who had not had braces before answering &#x201C;I don&#x2019;t know&#x201D;, compared to 5.6% of those who had had braces before (<xref ref-type="table" rid="ijms-3036920-t004">Table 4</xref>).</p>
      <p>Regarding whether orthodontic treatment results in more cavities, from the group who had not had braces before, almost almost twice as many answered that they &#x201C;don&#x2019;t know&#x201D; compared to those who had had braces (18.5% vs. 34.6%) (<xref ref-type="table" rid="ijms-3036920-t004">Table 4</xref>).</p>
      <p>Of the 132 participants in this study, only 59.1% had worn an orthodontic appliance in the past. </p>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <p>Malocclusion is a prevalent oral health condition, and how orthodontic treatment is perceived varies within a population. Patients&#x2019; perceptions and knowledge play key roles in their decision regarding whether to pursue treatment or not, and their behavior has the greatest influence on the success of orthodontic treatment. Most previous studies focused on the awareness component of health behavior. </p>
      <p>The current study found that the studied general population has a high level of knowledge about orthodontic treatment, but that this may be due to the majority of participants in the current study being women, since multiple studies have found women to have a greater awareness of orthodontic treatment than men [<xref ref-type="bibr" rid="B3-ijms-3036920">3</xref>,<xref ref-type="bibr" rid="B7-ijms-3036920">7</xref>].</p>
      <p>The majority of the respondents thought that orthodontic treatment is expensive, in contrast to other studies where orthodontic treatment was considered to be highly affordable [<xref ref-type="bibr" rid="B3-ijms-3036920">3</xref>]. This might be a consequence of the fact that, in Romania, general dental treatments are reimbursed by the National Health Insurance scheme at a rate of 60% on average, but there being no reimbursement for orthodontic treatments for adults. Thus, adults who seek orthodontic treatment need to cover their full treatment out of pocket [<xref ref-type="bibr" rid="B8-ijms-3036920">8</xref>].</p>
      <p>The overall perception of the participants was that after orthodontic treatment, patients smile more confidently, similar to another study conducted in Malaysia [<xref ref-type="bibr" rid="B3-ijms-3036920">3</xref>]. </p>
      <p>The current study showed that respondents have a high level of knowledge about the effects of orthodontic treatment, being aware that patient neglect can negatively affect the outcome of the treatment, with the lowest level of knowledge being that orthodontic treatment moves teeth. It is thought that the experience of pain is a very important factor that influences patient attitudes towards orthodontic treatment [<xref ref-type="bibr" rid="B5-ijms-3036920">5</xref>,<xref ref-type="bibr" rid="B9-ijms-3036920">9</xref>,<xref ref-type="bibr" rid="B10-ijms-3036920">10</xref>] and the majority of the participants in this study thought that the treatment would be painful. </p>
      <p>As for dental hygiene during treatment, patients were aware that they must use additional techniques in order to maintain a good level of hygiene, and that cavities are not a consequence of wearing an orthodontic appliance. Still, the need for frequent reinforcement of oral hygiene practices and motivation still exists, it already having been shown that constant reminders improve patient attitudes and oral health practices [<xref ref-type="bibr" rid="B11-ijms-3036920">11</xref>,<xref ref-type="bibr" rid="B12-ijms-3036920">12</xref>]. Multiple studies have described the appearance of a white spot lesion in the cervical area of a tooth after orthodontic treatment [<xref ref-type="bibr" rid="B13-ijms-3036920">13</xref>,<xref ref-type="bibr" rid="B14-ijms-3036920">14</xref>]. A study conducted in Romania showed that parents are still not aware on the benefits of fluoride use for white spots and had no correct information about the role of fluoride in oral health. Additionally, the habits of patients regarding fluoride use for their children remain inadequate [<xref ref-type="bibr" rid="B15-ijms-3036920">15</xref>].</p>
      <p>Most of the participants were aware that during orthodontic treatment there are food restrictions, and that failure to respect a doctor&#x2019;s recommendations can lead to a worsening of their health condition. </p>
      <p>The respondents in the current study were aware of the fact that, in order to maintain results, they need to wear a retainer. </p>
      <p>Even though only 59.1% had worn an orthodontic appliance in the past, the level of knowledge was high and perceptions positive. </p>
    </sec>
    <sec sec-type="conclusions">
      <title>Conclusions</title>
      <p>The current study shows that, overall, the majority of the studied population had a good level of understanding regarding orthodontic treatment, and a high level of knowledge about and a positive perception of it. </p>
      <p>The majority of the participants in the current study consider orthodontic treatment to be expensive and long-lasting, and they are aware that their attitude can influence treatment outcomes. </p>
      <p>Understanding the level of knowledge and perception of patients is a key factor in good collaboration between doctors and patients and helps dentists and their teams to better educate their patients. </p>
    </sec>
  </body>
  <back>
    <notes>
      <title>Author Contributions</title>
      <p>Conceptualization R-&#x218;.G. and R.S.; methodology, R-&#x218;.G. and R.S.; software, R-&#x218;.G.; validation, R-&#x218;.G., R.O., and R.S.; formal analysis, R.O.; investigation, R-&#x218;.G., R.O., and R.S.; resources, R-&#x218;.G.; data curation, R.O., and R.S.; writing&#x2014;original draft preparation, R-&#x218;.G., R.O.; writing&#x2014;review and editing, R.S.; visualization, R.O.; supervision, R.S.; project administration, R-&#x218;.G. and R.S. All authors have read and agreed to the published version of the manuscript.</p>
    </notes>
	<notes>
      <title>Funding</title>
      <p>This research received no external funding.</p>
    </notes>
    <notes notes-type="COI-statement">
      <title>Conflicts of Interest</title>
      <p>The authors declare no conflicts of interest. </p>
    </notes>
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