Timisoara Medical Journal

(ISSN: 1583-526X) Open Access Journal
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Timisoara Med 2021, 2021(1), 5; doi: 10.35995/tmj20210105

Effectiveness of Platelet-Rich Fibrin (PRF) Following Mandibular Third Molar Extraction: A Systematic Review

1 Department of Oral and Maxillofacial Surgery, Rajshahi Medical College, Rajshahi 6100, Bangladesh
2 Department of Pharmacology and Therapeutics, Sir Salimullah Medical College, Dhaka 1100, Bangladesh;
* Correspondence: ; Tel.: +880-1709681040
* Author to whom correspondence should be addressed.
Received: 25 Apr 2021 / Revised: 4 Jul 2021 / Accepted: 8 Jul 2021 / Published: 5 Aug 2021
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Abstract

(1) Purpose: The employment of platelet-rich fibrin (PRF) in the extracted teeth socket has been shown to aid tissue healing. It also minimizes detrimental consequences. The rationale of this systematic review is to observe the possible association between PRF employment and postoperative consequences following mandibular third molar surgery. (2) Materials and Methods: The following databases were explored electronically (till 28 February 2021): PubMed, Cochrane library, Embase, International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov. A manual explore was accomplished on various journals regarding the subject of oral and maxillofacial surgery. The online explore applied the keywords “platelet-rich fibrin or PRF,” and “mandibular third molar.” To review the efficiency of PRF, the accompanying post-operative consequences were collected: pain, swelling, trismus, inter-incisal distance, analgesic consumption, soft tissue healing, bone healing, socket complications, and periodontal parameters. (3) Results: Just 9 full-text studies out of 26 were comprised of review for qualitative analysis. All of the studies were randomized clinical trials (RCTs), with eight split-mouth designs and one parallel design study. Significant outcomes were usually observed for pain, postoperative swelling, mouth opening, periodontal pocket depth, soft tissue healing, and the incidence of alveolar osteitis or dry sockets, but not constantly. The qualitative scrutiny disclosed that the PRF had no considerable outcome in bone healing. (4) Conclusions: Local administration of PRF is a practical way of alleviating pain, trismus, oedema, and enhancing soft tissue healing following mandibular third molar extraction. PRF tends to have no function in bone healing following extraction. More controlled clinical trials and RCTs are necessitating exploring the end results of PRF following mandibular third molar extraction.
Keywords: extraction; mandibular third molar; platelet-rich fibrin (PRF)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
CITE
Rahman, A.S.; Jannat, T. Effectiveness of Platelet-Rich Fibrin (PRF) Following Mandibular Third Molar Extraction: A Systematic Review. Timisoara_Med 2021, 2021, 5.
Rahman AS, Jannat T. Effectiveness of Platelet-Rich Fibrin (PRF) Following Mandibular Third Molar Extraction: A Systematic Review. Timisoara Medical Journal. 2021; 2021(1):5.
Rahman, A.F.M. Shakilur; Jannat, Tamiral. 2021. "Effectiveness of Platelet-Rich Fibrin (PRF) Following Mandibular Third Molar Extraction: A Systematic Review." Timisoara_Med 2021, no. 1: 5.
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