Timisoara Medical Journal

(ISSN: 1583-526X) Open Access Journal
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Timisoara Med 2020, 2020(1), 3; doi: 10.35995/tmj20200103

COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test

Received: 15 Sep 2020 / Revised: 25 Sep 2020 / Accepted: 2020-10-14 / Published: 2020-10-21
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(1) Background: In the current clinical practice of the COVID-19 infection, the focus should not be placed on the positive RT-PCR results, but rather on the epidemiological, clinical, and imaging aspects specific to the disease. (2) Case Report: We present the case of a 34-year-old female, who had contacts with both her parents, both of whom were confirmed to have SARS-CoV-2 infection by RT-PCR testing. She presented for about one week symptoms suggestive of COVID-19 infection, determining her to repeatedly go to the emergency room, where she had three negative SARS-CoV-2 RT-PCR tests. The blood tests revealed leukopenia with lymphocytopenia, with increased lactate dehydrogenase (LDH) and C-reactive protein (CRP). Moreover, the chest X-ray showed modifications specific for COVID-19, and the diagnosis of COVID-19 was set. Drug treatment with hydroxychloroquine, azithromycin, cephalosporins, systemic corticosteroids, anticoagulants, bronchodilators, and interleukin-6 inhibitors was initiated, together with oxygen therapy. (3) Discussion: SARS-CoV-2 RT-PCR testing may give false negative results due to inadequate biological sampling, or to the accuracy of the test methods. A significant contribution to the diagnosis is made by the specific computed tomography (CT) criteria of COVID-19. (4) Conclusions: A priority for COVID-19 diagnosis accuracy is epidemiological investigation, together with clinical criteria and CT imaging, even in the presence of a negative RT-PCR test.
Keywords: COVID-19; SARS-CoV-2; negative RT-PCR; clinical characteristics; pneumonia; tomography; X-ray computed; case report
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Jurca, R.; Mihuța, C.; Tudorache, E.; Manolescu, D.; Oancea, C. COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test. Timisoara_Med 2020, 2020, 3.
Jurca R, Mihuța C, Tudorache E, Manolescu D, Oancea C. COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test. Timisoara Medical Journal. 2020; 2020(1):3.
Jurca, Roxana; Mihuța, Camil; Tudorache, Emanuela; Manolescu, Diana; Oancea, Cristian. 2020. "COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test." Timisoara_Med 2020, no. 1: 3.
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