Timisoara Med 2020, 2020(1), 3; doi: 10.35995/tmj20200103
COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test
Received: 15 Sep 2020 / Revised: 25 Sep 2020 / Accepted: 2020-10-14 / Published: 2020-10-21
(1) Background: In the current clinical practice of the COVID-19 infection, the focus should not be placed on the positive RT-PCR results, but rather on the epidemiological, clinical, and imaging aspects specific to the disease. (2) Case Report: We present the case of a 34-year-old female, who had contacts with both her parents, both of whom were confirmed to have SARS-CoV-2 infection by RT-PCR testing. She presented for about one week symptoms suggestive of COVID-19 infection, determining her to repeatedly go to the emergency room, where she had three negative SARS-CoV-2 RT-PCR tests. The blood tests revealed leukopenia with lymphocytopenia, with increased lactate dehydrogenase (LDH) and C-reactive protein (CRP). Moreover, the chest X-ray showed modifications specific for COVID-19, and the diagnosis of COVID-19 was set. Drug treatment with hydroxychloroquine, azithromycin, cephalosporins, systemic corticosteroids, anticoagulants, bronchodilators, and interleukin-6 inhibitors was initiated, together with oxygen therapy. (3) Discussion: SARS-CoV-2 RT-PCR testing may give false negative results due to inadequate biological sampling, or to the accuracy of the test methods. A significant contribution to the diagnosis is made by the specific computed tomography (CT) criteria of COVID-19. (4) Conclusions: A priority for COVID-19 diagnosis accuracy is epidemiological investigation, together with clinical criteria and CT imaging, even in the presence of a negative RT-PCR test.
Keywords: COVID-19; SARS-CoV-2; negative RT-PCR; clinical characteristics; pneumonia; tomography; X-ray computed; case report
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Jurca, R.; Mihuța, C.; Tudorache, E.; Manolescu, D.; Oancea, C. COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test. Timisoara_Med 2020, 2020, 3.
Jurca R, Mihuța C, Tudorache E, Manolescu D, Oancea C. COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test. Timisoara Medical Journal. 2020; 2020(1):3.
Jurca, Roxana; Mihuța, Camil; Tudorache, Emanuela; Manolescu, Diana; Oancea, Cristian. 2020. "COVID-19—Clinical Relevance of a Negative RT-PCR SARS-CoV-2 Test." Timisoara_Med 2020, no. 1: 3.