Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds
1 Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 E. Murgu Sq., 300041 Timisoara, Romania; (A.U.); (A.M.); (R.G.); (R.R.); (C.Ș.)
* Correspondence: ; Tel.: +40-756-236-715
† Authors with equal contribution, sharing the position of first author.
* Author to whom correspondence should be addressed.
Received: 11 Dec 2020 / Revised: 2 Feb 2021 / Accepted: 4 Feb 2021 / Published: 18 Feb 2021
Abstract
Pentacyclic triterpenes represent an important class of intensively studied substances in the past two decades due to their wide spectrum of pharmacological effects. Even though this class is being thoroughly researched for the development of new drugs, to date, no representative has qualified to become a suitable candidate for various therapies. Although a large part of past and ongoing studies focuses on triterpene chemical derivatization or formulation to increase its bioavailability, other researchers are focused on obtaining semisynthetic derivatives not necessarily with increased hydrophilicity but with a superior biological effect compared to their parent compound. The current review aims to report the biological assessment of several ring-modified pentacyclic triterpene derivative series.
Keywords: pentacyclic triterpenes; ring derivatization; synthetic derivatives; biological activity
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CITE
Ulici, A.; Milan, A.; Mioc, M.; Ghiulai, R.; Racoviceanu, R.; Șoica, C. Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds. Timisoara_Med 2021, 2020, 7.
Ulici A, Milan A, Mioc M, Ghiulai R, Racoviceanu R, Șoica C. Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds. Timisoara Medical Journal. 2021; 2020(2):7.
Ulici, Alexandra; Milan, Andreea; Mioc, Marius; Ghiulai, Roxana; Racoviceanu, Roxana; Șoica, Codruța. 2021. "Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds." Timisoara_Med 2020, no. 2: 7.
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